This dataset contains a summary of compounds found in human blood samples. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: The analyzed data cannot be made publicly available. Format: The original dataset contains identification information for the sample subjects and all of their descriptors including age, gender, race, and medical screening information. The analyzed data cannot be made publicly available. This dataset is associated with the following publication: Stiegel, M., J. Pleil , J. Sobus , and M. Madden. Inflammatory Cytokines and White Blood Cell Counts Response to Environmental Levels of Diesel Exhaust and Ozone Inhalation Exposures. PLoS ONE. Public Library of Science, San Francisco, CA, USA, 11(4): e0152458, (2016).

Data collected during the comparison of ozone responsiveness in primary bronchial epithelial cells from a range of distinct donors. This dataset is associated with the following publication: Bowers, E., S. McCullough, D. Morgan, L. Dailey, and D. Diaz-Sanchez. ERK1/2 and p38 regulate inter-individual variability in ozone-mediated IL-8 gene expression in primary human bronchial epithelial cells. Scientific Reports. Nature Publishing Group, London, UK, 8(1): 9398, (2018).

Data collected during the comparison of ozone responsiveness in primary bronchial epithelial cells from a range of distinct donors. This dataset is associated with the following publication: Bowers, E., S. McCullough, D. Morgan, L. Dailey, and D. Diaz-Sanchez. ERK1/2 and p38 regulate inter-individual variability in ozone-mediated IL-8 gene expression in primary human bronchial epithelial cells. Scientific Reports. Nature Publishing Group, London, UK, 8(1): 9398, (2018).

The dataset contains a list of cardiac and vascular biomarkers that were obtained on each day a participant visited the EPA Human Studies Facility. It also contains ozone concentrations on those days, which are publicly available on the EPA AirNow website. This dataset is not publicly accessible because: The dataset pertains to human research. It can be accessed through the following means: Requests to access data should be sent to Robert Devlin at devlin.robert@epa.gov. Format: The metadata are in the form of spreadsheets with health endpoints listed in columns and each human participant listed as a row. Similar spreadsheets contain exposure information in columns and participants in rows. This dataset is associated with the following publication: Mirowsky, J., M. Carraway, R. Dhingra, H. Tong, L. Neas, D. Diaz-Sanchez, W. Cascio, M. Case, J. Crooks, E. Hauser, E. Dowdy, W. Krause, and R. Devlin. Ozone exposure is associated with acute changes in inflammation, fibrinolysis, and endothelial cell function in coronary artery disease patients. ENVIRONMENTAL HEALTH. Academic Press Incorporated, Orlando, FL, USA, 16: 126, (2017).

The dataset contains a list of cardiac and vascular biomarkers that were obtained on each day a participant visited the EPA Human Studies Facility. It also contains ozone concentrations on those days, which are publicly available on the EPA AirNow website. This dataset is not publicly accessible because: The dataset pertains to human research. It can be accessed through the following means: Requests to access data should be sent to Robert Devlin at devlin.robert@epa.gov. Format: The metadata are in the form of spreadsheets with health endpoints listed in columns and each human participant listed as a row. Similar spreadsheets contain exposure information in columns and participants in rows. This dataset is associated with the following publication: Mirowsky, J., M. Carraway, R. Dhingra, H. Tong, L. Neas, D. Diaz-Sanchez, W. Cascio, M. Case, J. Crooks, E. Hauser, E. Dowdy, W. Krause, and R. Devlin. Ozone exposure is associated with acute changes in inflammation, fibrinolysis, and endothelial cell function in coronary artery disease patients. ENVIRONMENTAL HEALTH. Academic Press Incorporated, Orlando, FL, USA, 16: 126, (2017).

These data are from a human study collected under IRB protocol: ClinicalTrials.gov # NCT01874834. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: These data are from a human study collected under IRB protocol: ClinicalTrials.gov # NCT01874834. As such, it is a violation of Federal Law to publish them. Format: These data are from a human study collected under IRB protocol: ClinicalTrials.gov # NCT01874834. This dataset is associated with the following publication: Stiegel, M., J. Pleil, J. Sobus, T. Stevens, and M. Madden. Linking physiological parameters to perturbations in the human exposome: Environmental exposures modify blood pressure and lung function via inflammatory cytokine pathway. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. Taylor & Francis, Inc., Philadelphia, PA, USA, 80(9): 485-501, (2017).

These data are from a human study collected under IRB protocol: ClinicalTrials.gov # NCT01874834. This dataset is not publicly accessible because: EPA cannot release personally identifiable information regarding living individuals, according to the Privacy Act and the Freedom of Information Act (FOIA). This dataset contains information about human research subjects. Because there is potential to identify individual participants and disclose personal information, either alone or in combination with other datasets, individual level data are not appropriate to post for public access. Restricted access may be granted to authorized persons by contacting the party listed. It can be accessed through the following means: These data are from a human study collected under IRB protocol: ClinicalTrials.gov # NCT01874834. As such, it is a violation of Federal Law to publish them. Format: These data are from a human study collected under IRB protocol: ClinicalTrials.gov # NCT01874834. This dataset is associated with the following publication: Stiegel, M., J. Pleil, J. Sobus, T. Stevens, and M. Madden. Linking physiological parameters to perturbations in the human exposome: Environmental exposures modify blood pressure and lung function via inflammatory cytokine pathway. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. Taylor & Francis, Inc., Philadelphia, PA, USA, 80(9): 485-501, (2017).

Excel file of miRNA data. This dataset is associated with the following publication: Chen, H., S. Masood, A. Rappold, D. Diaz Sanchez, J. Samet, and H. Tong. The effects of controlled ozone exposure on circulating microRNAs and vascular and coagulation biomarkers: a mediation analysis. Non-Coding RNA. MDPI, Basel, SWITZERLAND, 9(4): 43, (2023).

This dataset includes data for the manuscript in progress, Intracerebroventricular kynurenic acid modulation differentially regulates the immune and neuroendocrine stress response to acute ozone exposure. This study employed the use of kynurenic acid or the kynurenic acid synthesis inhibitor, PF-04859989 infused into the dorsal third ventricle of the brain in male WKY rats, prior to acute ozone exposure at 0.8 ppm, to evaluate the role of kynurenic acid in modulating the neuroendocrine stress response to ozone. Our results indicate that kynurenic acid may have a protective role in the brain, in attenuating the pulmonary and systemic effects of ozone exposure, perhaps through multiple mechanisms. This dataset is associated with the following publication: Rentschler, K., M.C. Schladweiler, R. Grindstaff, W. Williams, P.R. Kodavanti, D. Freeborn, L. Klein, G. Jung, D. Herr, P. Evansky, J. McKee, S. Gavett, and U. Kodavanti. Differential Effects of Intracerebroventricular Kynurenic Acid Regulation on the Inflammatory and Neuroendocrine Response to Acute Ozone Exposure. Presented at Society of Toxicology, Orlando, FL, USA, 03/16/2025 - 03/20/2025.

These are the data for the figures in the manuscript. This dataset is associated with the following publication: Corteselli, E., A. Gold, J. Surratt, T. Cui, P. Bromberg, L. Dailey, and J. Samet. Supplementation with Omega-3 Fatty Acids Potentiates Oxidative Stress in Human Airway Epithelial Cells Exposed to Ozone. ENVIRONMENTAL RESEARCH. Elsevier B.V., Amsterdam, NETHERLANDS, 187: 109627, (2020).