cardiovascular responses of exposure to simulated smog atmospheres in animals. This dataset is associated with the following publication: Tong, H., J. Krug, T. Krantz, C. King, M. Hargrove, I. Gilmour, and S. Gavett. Inhalation of Simulated Smog Atmospheres Affects Cardiac Function in Mice#. Cardiovascular Toxicology. Humana Press Incorporated, Totowa, NJ, USA, 18(6): 569-578, (2019).

The dataset includes the draft main paper and supporting information file to be submitted to the journal, and also excel spread sheets containing the raw data which backs up the processed data used in the paper and supporting information file. Data include exposure characterization (temperature, RH, pollutant levels, etc.), physiology data, serum data, lung inflammation data, viral burden data, PCR data, blood data, lung pathology data, and other miscellaneous data. All the column headings and other relevant definitions and information are included in the data sets, and match the relevant data in the paper to be submitted. This dataset is associated with the following publication: Hargrove, M., S. Snow, R. Luebke, C. Wood, J. Krug, T. Krantz, C. King, C. Copeland, S. McCullough, K. Gowdy, U. Kodavanti, I. Gilmour, and S. Gavett. Effects of Simulated Smog Atmospheres in Rodent Models of Metabolic and Immunologic Dysfunction. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(5): 3062-3070, (2018).

The dataset includes the draft main paper and supporting information file to be submitted to the journal, and also excel spread sheets containing the raw data which backs up the processed data used in the paper and supporting information file. Data include exposure characterization (temperature, RH, pollutant levels, etc.), physiology data, serum data, lung inflammation data, viral burden data, PCR data, blood data, lung pathology data, and other miscellaneous data. All the column headings and other relevant definitions and information are included in the data sets, and match the relevant data in the paper to be submitted. This dataset is associated with the following publication: Hargrove, M., S. Snow, R. Luebke, C. Wood, J. Krug, T. Krantz, C. King, C. Copeland, S. McCullough, K. Gowdy, U. Kodavanti, I. Gilmour, and S. Gavett. Effects of Simulated Smog Atmospheres in Rodent Models of Metabolic and Immunologic Dysfunction. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(5): 3062-3070, (2018).

This dataset includes raw data used to generate figures for the manuscript describing the effects of noise and ozone on cardiovascular function in rats. This dataset is associated with the following publication: Hazari, M., K. Phillips, K. Stratford, A.M. Khan, L. Thompson, W. Oshiro, G. Hudson, D. Herr, and A. Farraj. Exposure to intermittent noise exacerbates the cardiovascular response of Wistar-Kyoto Rats to Ozone Inhalation and Arrhythmogenic Challenge. Cardiovascular Toxicology. Humana Press Incorporated, Totowa, NJ, USA, 21(4): 336-348, (2021).

The dataset contains the results of a study examining the impact of vitamin D deficiency on the cardiopulmonary response of mice to photochemical smog. This dataset is associated with the following publication: Stratford, K., N. Coates, L. Thompson, T. Krantz, C. King, J. Krug, I. Gilmour, A. Farraj, and M. Hazari. Early-Life Persistent Vitamin D Deficiency Alters Cardiopulmonary Responses to Particulate Matter-Enhanced Atmospheric Smog in Adult Mice. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 52(5): 3054-3061, (2018).

Cardiovascular Physiologic and Systemic Responses to Sequential Exposure to Nitrogen Dioxide and Ozone in Rats. This dataset is associated with the following publication: Farraj , A., F. Malik, N. Coates , L. Walsh , D. Winsett , D. Terrell , L. Thompson, W. Cascio , and M. Hazari. Morning NO2 Exposure Sensitizes Hypertensive Rats to the Cardiovascular Effects of Same Day O3 Exposure in the Afternoon. INHALATION TOXICOLOGY. Informa Healthcare USA, New York, NY, USA, 28(4): 170-179, (2016).

The dataset contains a list of cardiac and vascular biomarkers that were obtained on each day a participant visited the EPA Human Studies Facility. It also contains ozone concentrations on those days, which are publicly available on the EPA AirNow website. This dataset is not publicly accessible because: The dataset pertains to human research. It can be accessed through the following means: Requests to access data should be sent to Robert Devlin at devlin.robert@epa.gov. Format: The metadata are in the form of spreadsheets with health endpoints listed in columns and each human participant listed as a row. Similar spreadsheets contain exposure information in columns and participants in rows. This dataset is associated with the following publication: Mirowsky, J., M. Carraway, R. Dhingra, H. Tong, L. Neas, D. Diaz-Sanchez, W. Cascio, M. Case, J. Crooks, E. Hauser, E. Dowdy, W. Krause, and R. Devlin. Ozone exposure is associated with acute changes in inflammation, fibrinolysis, and endothelial cell function in coronary artery disease patients. ENVIRONMENTAL HEALTH. Academic Press Incorporated, Orlando, FL, USA, 16: 126, (2017).

This data set includes individual values for each animal that were used to calculate group means and standard deviations for all biological and functional data reported in the manuscript. This dataset is associated with the following publication: Martin, B., L. Thompson, Y. Kim, C. King, S. Snow, M.C. Schladweiler, N.H. Coates, I. George, I. Gilmour, U. Kodavanti, M. Hazari, and A. Farraj. Peat Smoke Inhalation Alters Blood Pressure, Baroreflex Sensitivity and Cardiac Arrhythmia Risk in Rats. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. Taylor & Francis, Inc., Philadelphia, PA, USA, 83(23-24): 748-763, (2020).

This data set includes individual values for each animal that were used to calculate group means and standard deviations for all biological and functional data reported in the manuscript. This dataset is associated with the following publication: Martin, B., L. Thompson, Y. Kim, C. King, S. Snow, M.C. Schladweiler, N.H. Coates, I. George, I. Gilmour, U. Kodavanti, M. Hazari, and A. Farraj. Peat Smoke Inhalation Alters Blood Pressure, Baroreflex Sensitivity and Cardiac Arrhythmia Risk in Rats. JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH - PART A: CURRENT ISSUES. Taylor & Francis, Inc., Philadelphia, PA, USA, 83(23-24): 748-763, (2020).

Pulmonary gene expression related to the regulation of DNA methylation following an exposure to ozone in rats. Epigenetic regulation of a pulmonary hypertensive gene, apelin, was also quantified. This dataset is associated with the following publication: Miller, C., J. Dye, M. Schladweiler, J. Richards, A. Ledbetter, E. Stewart, and U. Kodavanti. Acute inhalation of ozone induces DNA methylation of apelin in lungs of Long-Evans rats.. INHALATION TOXICOLOGY. Taylor & Francis, Inc., Philadelphia, PA, USA, 30(4): 178-186, (2018).